Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes
نویسندگان
چکیده
منابع مشابه
Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes.
Four different double-headed nucleosides each combining two thymine nucleobases with different linkers were synthesised. The 5-position of 2'-deoxyuridine was connected to the N1-position of a thymine through either m- or p-disubstituted phenyl or phenylacetylene linkers by the use of Suzuki or Sonogashira couplings. When introduced into oligonucleotides, the thermal stability of dsDNA and DNA ...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2015
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c5ob00872g